Predictive value of osteocalcin in bone metastatic differentiated thyroid carcinoma.

Abstract

OBJECTIVES:

To evaluate the diagnostic value of serum osteocalcin in the detection of bone metastases from differentiated thyroid carcinoma (DTC).

DESIGN AND METHODS:

Serum samples from DTC patients with (DTC BM+, n=19) or without bone metastases (DTC BM-, n=19), and matched healthy volunteers (n=30) were tested for serum osteocalcin with electrochemiluminescent immunoassay.

RESULTS:

Osteocalcin was higher in DTC BM+ than in DTC BM- patients (+35.8%, p=0.002), acting as an independent risk factor for bone metastases (R(2)=0.142, p=0.039). The sensitivity was 78.9% and the specificity was 63.2% at a cut-off value of 11.2 microg/L.

CONCLUSIONS:

Serial measurements of osteocalcin could be useful in the detection of bone metastases from DTC.

• Authors: Yunchao Gao, Hankui Lu, Qiong Luo, Xiaohui Wu, Shiwei Sheng
• Journal: Clinical biochemistry (Clin Biochem) Vol. 43 Issue 3 Pg. 291-5 (Feb 2010) ISSN: 1873-2933 [Electronic] United States
• PMID: 19732762 (Publication Type: Journal Article)
• Copyright: (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Collagen Type I
• Procollagen
• Osteocalcin
• Alkaline Phosphatase

Topics

• Alkaline Phosphatase (blood)
• Biomarkers, Tumor (blood)
• Bone Neoplasms (blood, secondary)
• Collagen Type I (blood)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Osteocalcin (blood)
• Procollagen (blood)
• Thyroid Neoplasms (blood, pathology)