Subcutaneous anti-D treatment of idiopathic thrombocytopenic purpura in children.

Abstract

We investigated the effect of subcutaneous anti-D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty-three children were treated with subcutaneous anti-D 50 microg/kg. The median platelet count increased from 7 x 10(9) to 31 x 10(9)/L on day 3 (P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self-limiting with no effect on activity level. These results suggest subcutaneous anti-D IgG 50 microg/kg as an effective and well-tolerated treatment option in childhood ITP.

• Authors: Mimi Kjaersgaard, Pernille Wendtland Edslev, Henrik Hasle
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 53 Issue 7 Pg. 1315-7 (Dec 15 2009) ISSN: 1545-5017 [Electronic] United States
• PMID: 19722275 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2009 Wiley-Liss, Inc.

Chemical References

• Hemoglobins
• Isoantibodies
• RHO(D) antibody
• Rho(D) Immune Globulin

Topics

• Adolescent
• Child
• Child, Preschool
• Chills (etiology)
• Female
• Fever (etiology)
• Hemoglobins (analysis)
• Hemorrhage (etiology)
• Humans
• Immunotherapy
• Infant
• Injections, Subcutaneous
• Isoantibodies (administration & dosage, adverse effects, therapeutic use)
• Male
• Pain (etiology)
• Platelet Count
• Prospective Studies
• Purpura, Thrombocytopenic, Idiopathic (blood, complications, therapy)
• Rho(D) Immune Globulin