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Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression.

Abstract
The selective 5-HT1A receptor ligand ipsapirone (IPS) induces hypothermia in humans. To explore 5-HT1A receptor-mediated thermoregulation in depression, 24 subjects (12 patients with unipolar depression and 12 individually matched controls) received 0.3 mg/kg IPS or placebo in random order. Compared with controls, the depressed patients exhibited significantly attenuated hypothermic responses to IPS. The impaired hypothermic response following 5-HT1A receptor activation in unipolar depression could have resulted from subsensitivity of the (presynaptic) 5-HT1A receptor and/or related effector mechanisms, thus supporting the hypothesis that altered serotonergic activity may be present in affective disorders. Future studies of the hypothermic response to direct-acting 5-HT1A ligands, such as IPS should facilitate the assessment of 5-HT receptor function in various affective disorders and its involvement in psychotropic drug effects.
AuthorsK P Lesch, S Mayer, J Disselkamp-Tietze, A Hoh, G Schoellnhammer, H M Schulte
JournalLife sciences (Life Sci) Vol. 46 Issue 18 Pg. 1271-7 ( 1990) ISSN: 0024-3205 [Print] Netherlands
PMID1971701 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Anxiety Agents
  • Ligands
  • Pyrimidines
  • Receptors, Serotonin
  • ipsapirone
Topics
  • Anti-Anxiety Agents (pharmacology)
  • Body Temperature
  • Body Temperature Regulation (drug effects)
  • Depressive Disorder (metabolism)
  • Double-Blind Method
  • Female
  • Humans
  • Hypothermia, Induced
  • Ligands
  • Male
  • Pyrimidines (pharmacology)
  • Random Allocation
  • Receptors, Serotonin (drug effects, metabolism)
  • Recurrence

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