HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers.

Abstract
Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its unique expression pattern limited to tumor-associated endothelial cells, PSMA may also be an interesting molecule for vascular targeting. In this study, PSMA expression was determined by immunohistochemistry in 119 cases of primary gastric adenocarcinoma, 130 cases of primary colorectal adenocarcinoma, and 24 metastasis of colorectal adenocarcinoma. Expression data were correlated with clinicopathologic information. PSMA expression was detected in tumor-associated neovasculature of 79 (66%) of 119 gastric and 110 (85%) of 130 colorectal carcinomas. Furthermore, the neovasculatures of 16 (84%) of 19 liver and 4 (80%) of 5 nodal metastases from colorectal carcinomas were prostate-specific membrane antigen positive. There was a trend for high-grade tumors to higher PSMA expression (Spearman r = 0.18, P = .046) in colorectal cancers. No association between PSMA expression and overall- or disease-free survival was observed in gastric or colorectal cancers. This study provides the first in-depth look at PSMA expression in gastric and colorectal cancer. Because of its highly tumor-restricted expression and its accessibility to targeted therapy, PSMA represents a promising therapeutic and diagnostic target in colorectal and gastric cancer.
AuthorsMichael C Haffner, Irmgard E Kronberger, Jeffrey S Ross, Christine E Sheehan, Matthias Zitt, Gilbert Mühlmann, Dietmar Ofner, Bettina Zelger, Christian Ensinger, Ximing J Yang, Stephan Geley, Raimund Margreiter, Neil H Bander
JournalHuman pathology (Hum Pathol) Vol. 40 Issue 12 Pg. 1754-61 (Dec 2009) ISSN: 1532-8392 [Electronic] United States
PMID19716160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Surface
  • Biomarkers, Tumor
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II
Topics
  • Adenocarcinoma (blood supply, metabolism)
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Surface (biosynthesis)
  • Biomarkers, Tumor (analysis)
  • Colorectal Neoplasms (blood supply, metabolism)
  • Female
  • Fluorescent Antibody Technique
  • Glutamate Carboxypeptidase II (biosynthesis)
  • Humans
  • Immunohistochemistry
  • Male
  • Microscopy, Confocal
  • Middle Aged
  • Neoplasm Staging
  • Neovascularization, Pathologic (metabolism)
  • Prognosis
  • Stomach Neoplasms (blood supply, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: