The vaso-vagal nature of
syncopes which remained unexplained despite full clinical and electrophysiological investigation was evaluated by means of 60 degrees head-up tilt test for 60 minutes. Thirty patients (16 men and 14 women, mean age 63.6 years, 19 with and 11 without organic
heart disease) with 1 to 28 (mean 5.1) episodes of
syncope of unknown origin were studied together with 11 asymptomatic control subjects. Head-up tilt test was considered positive if
syncope developed in association with
hypotension and/or
bradycardia. During baseline head-up tilt 15 patients (50%) showed a positive test, with vasodepressor response (marked
hypotension without marked
bradycardia) in 10 cases and with mixed response (marked
hypotension with marked
bradycardia) in 5 cases. None of the control subjects became symptomatic during the test. Mean time to
syncope was 24.9 minutes. Baseline head-up tilt test was reproducibly positive in 10 out of 14 patients (71%). Eight of these 10 patients underwent serial head-up tilt tests after
atropine (0.04 mg/Kg i.v. in 1 minute),
propranolol (0.2 mg/Kg i.v. in 3 minutes) and
etilefrin (15-30 mg/day orally for 2-3 days) to determine the pathogenesis of vaso-vagal
syncope.
Atropine prevented tilt-induced
syncope in 3 out of 7 patients (43%),
propranolol in 2 out of 7 (29%) and etilephrine in 6 out of 6 (100%). Seven patients were chronically treated with drugs selected on the basis of acute
drug testing. One patient-responder to
atropine received transdermal
scopolamine and the other 6 received etilephrine. None of these 7 patients had syncopal recurrences or death during a mean follow-up of 7.7 months, except 1 who experienced another episode of
syncope after having discontinued etilephrine 4 months before. These results suggest that: 1) head-up tilt is a very sensitive and highly specific test to unmask susceptibility to vaso-vagal reaction in patients with
syncope of unknown origin; 2) withdrawal of alpha-sympathetic stimulation is the principal mechanism responsible for vasodilation and
syncope during head-up tilt; 3) alpha-
sympathomimetic agents, such as etilephrine, are effective in preventing spontaneous episodes of vaso-vagal
syncope during a short-term follow-up.