[Multicenter study of the effectiveness and tolerance of clotiazepam in cardiology].

In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. The dosage was 5-10 mg TID, and the treatment lasted for 3 weeks. Variations of the dosage were requested in 21% of patients and generally at the 2nd week of treatment. The safety of clotiazepam was good: only in the 14% of patients side-effects were observed (especially drowsiness 9.3% and asthenia 2.3%). Clotiazepam was judged to be effective in 75% of patients. The Hamilton psychiatric rating scale for anxiety showed a progressive decrease both of the total score and of the scores of every item; the cardiovascular symptoms particularly improved at both the controls.
AuthorsL Colonna, F Cozzi, F Del Citerna, A Di Benedetto, O De Divitiis, F Furlanello, F Milazzotto, M Pittalis, A Taccola
JournalMinerva cardioangiologica (Minerva Cardioangiol) 1990 Jan-Feb Vol. 38 Issue 1-2 Pg. 45-9 ISSN: 0026-4725 [Print] ITALY
Vernacular TitleStudio policentrico sull'efficacia e tollerabilità del clotiazepam in cardiologia.
PMID1971433 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
Chemical References
  • Azepines
  • Adolescent
  • Adult
  • Aged
  • Anxiety (complications, drug therapy)
  • Azepines (administration & dosage, therapeutic use)
  • Cardiovascular Diseases (psychology)
  • Drug Evaluation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multicenter Studies as Topic
  • Psychiatric Status Rating Scales

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