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The protective effect of oxygenated perfluorocarbons (PFCs) on intestinal ischemia reperfusion injury (I/R) in rabbits.

AbstractOBJECTIVE:
To evaluate the effect of intraluminal administration of oxygenated perfluorocarbons (PFCs) on small intestine's viability in an experimental model of acute ischemia-reperfusion (I/R).
METHODS:
Twenty rabbits were divided in four groups: sham-operated controls (group A), acute I/R (group B), acute I/R plus infusion of PFCs 30 min before ischemia (group C), and acute I/R plus infusion of PFCs 30 min before reperfusion (group D). Malondialdehyde (MDA) tissue levels and d-lactate blood samples were taken. All tissue sections were examined under light microscope.
RESULTS:
Mean MDA levels in group A: 1.79 +/- 0.97 at 0 min, 2.25 +/- 1.76 at 120 min and 3.70 +/- 1.76 nmols/g at 180 min. Group B: 2.60 +/- 0.58 at 0 min, 4.20 +/- 0.58 at 120 min and 5.48 +/- 2.01 at 180 min. Group C: 1.54 +/- 0.85 at 0 min, 1.14 +/- 0.37 at 120 min and 0.59 +/- 0.35 at 180 min. Group D: 2.12 +/- 0.62 at 0 min, 3.97 +/- 0.70 at 120 min and 2.32 +/- 0.37 at 180 min (p < 0.05). Mean d-lactate levels in group A: at 0 min 36.45 +/- 1.99, at 120 min 39.10 +/- 2.37 and at 180 min 40.05 +/- 2.13 mg/dl. Group B: 61.23 +/- 11.03 at 0 min, 74.84 +/- 10.70 at 120 min and 89.90 +/- 9.29 at 180 min. Group C: at 0 min 51.05 +/- 10.36, at 120 min 56.07 +/- 11.27 and at 180 min 57.20 +/- 11.19. Group D: 64.36 +/- 5.26 at 0 min, 72.55 +/- 7.19 at 120 min and 77.02 +/- 9.41 at 180 min (p < 0.05). Histopathological analysis indicated a significant improvement in the groups of oxygenated PFCs compared with I/R group.
CONCLUSION:
Intraluminal administration of oxygenated PFCs seems that protect the intestine from the I/R injury.
AuthorsAchilleas Ntinas, Stavros Iliadis, Athanasia Alvanou Achparaki, Dionisios Vrochides, Georgios Pitoulias, Georgios Papageorgiou, Charalambos Spyridis, Dimitrios Papadimitriou, Dimitrios Karamanos, Thomas Gerasimidis
JournalVascular and endovascular surgery (Vasc Endovascular Surg) Vol. 44 Issue 2 Pg. 81-8 (Feb 2010) ISSN: 1938-9116 [Electronic] United States
PMID19713271 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fluorocarbons
  • Protective Agents
  • Lactic Acid
  • Malondialdehyde
  • Oxygen
Topics
  • Animals
  • Cell Survival
  • Cytoprotection
  • Disease Models, Animal
  • Fluorocarbons (administration & dosage)
  • Infusions, Parenteral
  • Intestinal Mucosa (metabolism)
  • Intestines (blood supply, drug effects, pathology)
  • Lactic Acid (blood)
  • Malondialdehyde (metabolism)
  • Oxygen (administration & dosage)
  • Protective Agents (administration & dosage)
  • Rabbits
  • Reperfusion Injury (metabolism, pathology, prevention & control)
  • Time Factors

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