Abstract | OBJECTIVE: METHODS: RESULTS: Heart function was severely depressed 6 hours after coronary artery occlusion, but recovered significantly under the influence of ribose. Left ventricular (LV) systolic pressure (LVSP) and contractility (LVdP/dtmax) were restored to the normal levels of sham-operated animals, while parameters of LV relaxation (LVdP/dtmin and time constant of relaxation tau) were impaired compared to sham-operated animals, but significantly improved by ribose treatment compared to sham-treated MI-rats. Moreover, the infarct size was significantly smaller in the ribose treated animals despite a comparable ischemic area at risk in all MI-rats. The cytokine mRNA expression after MI was significantly reduced after ribose treatment, while there were no differences regarding MMP expression. CONCLUSION: MI size was significantly reduced and LV function significantly improved by ribose treatment at 6 h after MI. This seemed to be based on slowing the velocity of the necrotic wave front across the LV wall after MI resulting in smaller infarcts.
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Authors | Germán E Gonzalez, Steffen Rabald, Wilfried Briest, Ricardo J Gelpi, Ignacio Seropian, Heinz-Gerd Zimmer, Alexander Deten |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 24
Issue 3-4
Pg. 211-8
( 2009)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 19710536
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2009 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Animals
- Female
- Heart
(drug effects, physiopathology)
- Hemodynamics
(drug effects)
- Infarction
(pathology)
- Myocardial Infarction
(drug therapy, physiopathology)
- Myocardium
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Ribose
(pharmacology)
- Ventricular Dysfunction, Left
(physiopathology, prevention & control)
- Ventricular Function, Left
(drug effects)
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