Abstract | OBJECTIVE: Previous studies reported that the clinical significance of intra-amniotic inflammation with a negative amniotic fluid (AF) culture is similar to that of intra-amniotic inflammation with microbiologically-proven AF infection. However, the magnitude of the fetal inflammatory response in these two conditions is different as gauged by umbilical cord C-reactive protein (CRP) concentrations. We undertook this study to determine if the frequency of oligohydramnios is different in these two conditions. METHODS: The amniotic fluid index (AFI) was measured in 205 patients with preterm premature rupture of membranes (PROM) (<or=35 weeks). AF was cultured for aerobic and anaerobic bacteria and genital mycoplasmas. Intra-amniotic inflammation was defined as an elevated AF matrix metalloproteinase-8 (MMP-8) concentration (>23 ng/mL). Patients were divided into three groups according to the results of AF culture and the presence or absence of intra-amniotic inflammation: 1) without intra-amniotic inflammation and a negative culture (n=109); 2) with intra-amniotic inflammation and a negative culture (n=44); and 3) a positive culture (n=52). RESULTS: Patients with a positive culture had a higher frequency of oligohydramnios and a lower median AFI than those with a negative culture but with intra-amniotic inflammation (P<0.01). However, there was no significant difference in the median AFI or in the frequency of oligo- hydramnios according to the presence or absence of intra-amniotic inflammation among patients with a negative culture (P>0.1). CONCLUSION:
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Authors | Si Eun Lee, Roberto Romero, Seung Mi Lee, Bo Hyun Yoon |
Journal | Journal of perinatal medicine
(J Perinat Med)
Vol. 38
Issue 1
Pg. 39-44
( 2010)
ISSN: 1619-3997 [Electronic] Germany |
PMID | 19708825
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Amniotic Fluid
(microbiology)
- Chorioamnionitis
(microbiology)
- Female
- Fetal Diseases
(etiology)
- Humans
- Oligohydramnios
(microbiology)
- Pregnancy
- Systemic Inflammatory Response Syndrome
(etiology)
- Young Adult
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