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[Use of guinea pigs to evaluate the efficacy of a heterological immunoglobulin against Bolivian hemorrhagic fever].

Abstract
The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the protective properties of a heterological immunoglobulin against Bolivian hemorrhagic fever at the preclinical stage of the study. A highly pathogenic Machupo virus strain that caused guinea pigs' death with respect with an agent's dose was cultivated. Injection of 1.0 ml of the immunoglobulin provided a 100% protective effect for the guinea pigs infected with the highly pathogenic Machupo virus strain in a dose of 10 LD50.
AuthorsA L Khmelev, I V Borisevich, V B Pantiukhov, A P Pirozhkov, S I Syromiatnikova, I V Shatokhina, S A Mel'nikov, E E Shagarov
JournalVoprosy virusologii (Vopr Virusol) 2009 Jul-Aug Vol. 54 Issue 4 Pg. 42-4 ISSN: 0507-4088 [Print] Russia (Federation)
PMID19708556 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Immunoglobulins
Topics
  • Animals
  • Arenaviridae Infections (therapy)
  • Arenaviruses, New World
  • Disease Models, Animal
  • Dose-Response Relationship, Immunologic
  • Drug Evaluation, Preclinical
  • Guinea Pigs
  • Immunoglobulins (administration & dosage, immunology)
  • Injections, Intramuscular

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