Abstract |
The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the protective properties of a heterological immunoglobulin against Bolivian hemorrhagic fever at the preclinical stage of the study. A highly pathogenic Machupo virus strain that caused guinea pigs' death with respect with an agent's dose was cultivated. Injection of 1.0 ml of the immunoglobulin provided a 100% protective effect for the guinea pigs infected with the highly pathogenic Machupo virus strain in a dose of 10 LD50.
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Authors | A L Khmelev, I V Borisevich, V B Pantiukhov, A P Pirozhkov, S I Syromiatnikova, I V Shatokhina, S A Mel'nikov, E E Shagarov |
Journal | Voprosy virusologii
(Vopr Virusol)
2009 Jul-Aug
Vol. 54
Issue 4
Pg. 42-4
ISSN: 0507-4088 [Print] Russia (Federation) |
PMID | 19708556
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Animals
- Arenaviridae Infections
(therapy)
- Arenaviruses, New World
- Disease Models, Animal
- Dose-Response Relationship, Immunologic
- Drug Evaluation, Preclinical
- Guinea Pigs
- Immunoglobulins
(administration & dosage, immunology)
- Injections, Intramuscular
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