Keloid treatment: is there a role for acellular human dermis (Alloderm)?

Abstract

BACKGROUND:

Keloid management is faced with high recurrence rates. Keloid fibroblasts lack the normal negative feedback mechanism resulting in an exuberant scar formation. Alloderm doesn't undergo the same proliferative process as keloidal scar dermis.

OBJECTIVE:

To evaluate Alloderm as a treatment modality for keloids

METHODS:

A retrospective chart review of six patients with a total of eight large recurrent keloids was performed. Patients were treated with excision of the keloid followed by placement of Alloderm. Each patient was evaluated for recurrence and complications.

RESULTS:

During follow-up ranging from 1 month to 4(1/2) years there were 0% recurrences. Two out of 8 (25%) had residual induration. one of the two patients with residual induration, required an intralesional injection of kenalog at 6 months post-op.

CONCLUSION:

Our results from this small study show that with the use of Alloderm after keloid excision, recurrence is low. Further study is warranted.

• Authors: Nima P Patel, A Lawrence Cervino
• Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS (J Plast Reconstr Aesthet Surg) Vol. 63 Issue 8 Pg. 1344-8 (Aug 2010) ISSN: 1878-0539 [Electronic] Netherlands
• PMID: 19699700 (Publication Type: Journal Article)
• Copyright: Copyright 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Alloderm
• Glucocorticoids
• Collagen
• Triamcinolone Acetonide

Topics

• Child
• Collagen (therapeutic use)
• Female
• Follow-Up Studies
• Glucocorticoids (administration & dosage)
• Humans
• Injections, Intralesional
• Keloid (therapy)
• Male
• Middle Aged
• Plastic Surgery Procedures (methods)
• Retrospective Studies
• Skin, Artificial
• Time Factors
• Treatment Outcome
• Triamcinolone Acetonide (administration & dosage)
• Young Adult