Abstract |
Tumor necrosis factor receptor-associated factor 1 ( TRAF1) is unique among the members of the TRAF family, as it lacks the N-terminal RING/zinc-finger domain. Also the function of TRAF1 is not clearly established, with many papers reporting contradictory results. Here we show that TRAF1 interacts with BAFF receptor, a member of the TNF receptor family, and positively regulates activation of the alternative NF-kappaB pathway. Ectopic expression of TRAF1 causes degradation of TRAF3, stabilization of NIK, and processing of p100 to produce the mature form p52. In addition, we show that knocking-down expression of TRAF1 in the Hodgkin's disease derived cell line L1236, interfere with p100 processing and with p52 mediate gene transcription. Collectively these results support a role for TRAF1 as a positive regulator of the NF-kappaB alternative pathway.
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Authors | Alfonso Lavorgna, Rosaria De Filippi, Silvestro Formisano, Antonio Leonardi |
Journal | Molecular immunology
(Mol Immunol)
Vol. 46
Issue 16
Pg. 3278-82
(Oct 2009)
ISSN: 1872-9142 [Electronic] England |
PMID | 19698991
(Publication Type: Journal Article)
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Chemical References |
- B-Cell Activation Factor Receptor
- NF-kappa B
- TNF Receptor-Associated Factor 1
- TNF Receptor-Associated Factor 3
- TNFRSF13C protein, human
- TRAF3 protein, human
- Protein Serine-Threonine Kinases
- NF-kappa B kinase
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Topics |
- B-Cell Activation Factor Receptor
(biosynthesis, genetics, immunology)
- Cell Line, Tumor
- Gene Expression
- Hodgkin Disease
(genetics, immunology, metabolism)
- Humans
- NF-kappa B
(genetics, immunology, metabolism)
- Protein Serine-Threonine Kinases
(genetics, immunology, metabolism)
- Protein Stability
- TNF Receptor-Associated Factor 1
(biosynthesis, genetics, immunology)
- TNF Receptor-Associated Factor 3
(genetics, immunology, metabolism)
- Zinc Fingers
(genetics, immunology)
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