[Evaluation of carbetocin (pabal) efficacy in the prevention of the postpartum hemorrhage in women after cesarean section--preliminary report].

Abstract

OBJECTIVES:

The aim of this study was to evaluate the efficacy of carbetocin in prevention of PPH in women after cesarean section.

MATERIAL AND METHODS:

We enrolled 60 patients who had undergone cesarean section in tertiary referential center, Department of Perinatology, Medical University of Lodz, Poland, between January and June 2008. Each patient obtained a single 100 microg dose of carbetocin intravenously during cesarean section, immediately after the delivery of the baby and prior to the delivery of the placenta. We evaluated postoperative blood parameters in 2 and 12 hours after the operation, the proportion of patients requiring additional uterotonic agents and adverse events in the whole population and in the group of women with high risk of PPH.

RESULTS:

58.1% of patients underwent emergency and 41.3% elective cesarean section delivery. The risk factor of PPH was identified in 38 women (63.3%). The results of this study indicate that carbetocin produces rapid and long-lasting uterine tone. A small drop in mean hemoglobin and hematocrit levels 2 and 12 hours after the operation was observed. 15% of patients required the use of additional uterotonic agents. In the group of women with high risk of PPH, carbetocin appeared to be effective in 79% of the patients. Only 11.4% of patients had minor adverse events.

CONCLUSIONS:

Carbetocin appears to be an effective new drug in the prevention of postpartum hemorrhage, not only among women undergoing cesarean section but also in the group of women with PPH risk factors.

• Authors: Jarosław Kalinka, Małgorzata Lipińska, Dariusz Sosnowski, Wojciech Wiliński, Michał Skoczylas, Marcin Serafin, Maria Prośniewska, Paweł Krajewski, Tadeusz Laudański
• Journal: Ginekologia polska (Ginekol Pol) Vol. 80 Issue 7 Pg. 512-7 (Jul 2009) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Ocena skuteczności stosowania karbetocyny w profilaktyce krwawień poporodowych u kobiet po cieciu cesarskim--doniesienie wstepne.
• PMID: 19697815 (Publication Type: Clinical Conference, English Abstract, Journal Article)

Chemical References

• Delayed-Action Preparations
• Oxytocin
• carbetocin

Topics

• Adult
• Cesarean Section (adverse effects)
• Delayed-Action Preparations (administration & dosage)
• Female
• Humans
• Infant, Newborn
• Intraoperative Care
• Oxytocin (administration & dosage, analogs & derivatives)
• Poland
• Postoperative Hemorrhage (etiology, prevention & control)
• Postpartum Hemorrhage (etiology, prevention & control)
• Pregnancy
• Treatment Outcome