Abstract | AIMS: The aim was to assess the value of GCC in distinguishing primary ovarian mucinous neoplasms from metastatic mucinous adenocarcinomas with ovarian involvement. Guanylyl cyclase C (GCC) is a brush border membrane receptor for the endogenous peptides guanylin and uroguanylin, and the homologous diarrhoeagenic bacterial heat-stable enterotoxins that is selectively expressed by epithelial cells from the duodenum to the rectum, but not by normal epithelia of the stomach or oesophagus, or normal extramucosal cells in humans. METHODS AND RESULTS: CONCLUSIONS: GCC is a useful marker for differentiating between primary and secondary ovarian mucinous neoplasms.
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Authors | Vincenzo Ciocca, Alessandro Bombonati, Juan P Palazzo, Stephanie Schulz, Scott A Waldman |
Journal | Histopathology
(Histopathology)
Vol. 55
Issue 2
Pg. 182-8
(Aug 2009)
ISSN: 1365-2559 [Electronic] England |
PMID | 19694825
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Receptors, Peptide
- Guanylate Cyclase
- Receptors, Enterotoxin
- Receptors, Guanylate Cyclase-Coupled
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Topics |
- Adenocarcinoma, Mucinous
(pathology, secondary)
- Adult
- Aged
- Appendiceal Neoplasms
(pathology)
- Biomarkers, Tumor
- Colorectal Neoplasms
(pathology)
- Cystadenocarcinoma
(secondary)
- Cystadenoma, Mucinous
(secondary)
- Female
- Guanylate Cyclase
(metabolism)
- Humans
- Middle Aged
- Ovarian Neoplasms
(pathology, secondary)
- Receptors, Enterotoxin
- Receptors, Guanylate Cyclase-Coupled
- Receptors, Peptide
(metabolism)
- Retrospective Studies
- Stomach Neoplasms
(secondary)
- Tumor Burden
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