[A case of stage IV AFP producing cecal cancer responding to mFOLFOX6 leading to a partial response].

Abstract

We report a case of stage IV AFP producing cecal cancer responding to mFOLFOX6 leading to a partial response. The patient was a 72-year-old female with multiple liver metastases of cecal cancer. She underwent a right hemicolectomy and right salpingo-oophorectomy in a non-curative resection. Final findings revealed cecal cancer, type 3, 60 x 55 mm, pSI (right ovary), pN3, sH3, sP0, cM0, fStage IV, respectively. After surgery, chemotherapy with mFOLFOX6 was performed. After 4 courses, a significant tumor reduction (PR) was obtained. She died 1 year 2 months after surgery. This case suggests that chemotherapy with mFOLFOX6 is a potential regimen for AFP producing colon cancer.

• Authors: Ken Seshimo, Yutaka Yamashita, Masahiro Oishi, Naosuke Yokomichi, Hideaki Ikeda, Hiroshi Katoh, Masao Yamamura, Masahito Kodera, Reijiro Maejima, Keita Kobayashi, Keiko Takita
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 8 Pg. 1375-7 (Aug 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19692783 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Organoplatinum Compounds
• alpha-Fetoproteins
• Leucovorin
• Fluorouracil

Topics

• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cecal Neoplasms (drug therapy, metabolism)
• Female
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Organoplatinum Compounds (administration & dosage)
• alpha-Fetoproteins (biosynthesis)