Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability?

Abstract

Antioxidant capacities of captopril (CAP), 6-mercaptopurine (6-MP) and 9-(beta-D-ribofuranosyl)-6-mercaptopurine (6-MPR) were investigated by interacting them with 2,2'-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical, and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cation radical (ABTS(+)(*)), and by protecting DNA and erythrocyte against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) induced oxidation. It was found that CAP possessed the highest ability to donate the hydrogen atom in -SH to DPPH and galvinoxyl, while 6-MPR had the strongest ability to reduce ABTS(+)(*). In the process of protecting DNA and erythrocytes against AAPH-induced oxidation, CAP can trap 0.5 and 1.3 radicals, 6-MP can trap 0.6 and 2.2, and 6-MPR can trap 1.0 and 3.0 radicals, respectively. CAP can also protect erythrocytes against hemin-induced hemolysis.

• Authors: Guo-Xiang Li, Zai-Qun Liu
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 44 Issue 12 Pg. 4841-7 (Dec 2009) ISSN: 1768-3254 [Electronic] France
• PMID: 19692149 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Free Radical Scavengers
• Sulfhydryl Compounds
• Hemin
• Captopril
• Mercaptopurine

Topics

• Antioxidants (pharmacology)
• Captopril (chemistry, pharmacology)
• Erythrocytes (drug effects, metabolism)
• Free Radical Scavengers (pharmacology)
• Hemin (chemistry)
• Hemolysis (drug effects)
• Humans
• Mercaptopurine (chemistry, pharmacology)
• Molecular Structure
• Sulfhydryl Compounds (chemistry)