Abstract | OBJECTIVE: DATA SOURCES: Human clinical studies, veterinary experimental studies, forum proceedings, book chapters, and American Heart Association guidelines. HUMAN AND VETERINARY DATA SYNTHESIS: Septic shock is the most common form of vasodilatory shock. The exogenous administration of vasopressin in animal models of fluid-resuscitated septic and hemorrhagic shock significantly increases mean arterial pressure and improves survival. The effect of vasopressin on return to spontaneous circulation, initial cardiac rhythm, and survival compared with epinephrine is mixed. Improved survival in human patients with ventricular fibrillation, pulseless ventricular tachycardia, and nonspecific cardiopulmonary arrest has been observed in 4 small studies of vasopressin versus epinephrine. Three large studies, though, did not find a significant difference between vasopressin and epinephrine in patients with cardiopulmonary arrest regardless of initial cardiac rhythm. No veterinary clinical trials have been performed using vasopressin in cardiopulmonary arrest. CONCLUSION:
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Authors | Richard D Scroggin Jr, Jane Quandt |
Journal | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
(J Vet Emerg Crit Care (San Antonio))
Vol. 19
Issue 2
Pg. 145-57
(Apr 2009)
ISSN: 1476-4431 [Electronic] United States |
PMID | 19691565
(Publication Type: Journal Article, Review)
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Chemical References |
- Vasoconstrictor Agents
- Vasopressins
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Topics |
- Animals
- Animals, Domestic
- Heart Arrest
(drug therapy, veterinary)
- Humans
- Shock
(drug therapy, veterinary)
- Vasoconstrictor Agents
(therapeutic use)
- Vasopressins
(therapeutic use)
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