Abstract |
Leukotriene B4 ( LTB4) and prostaglandin E2 ( PGE2) concentrations were measured in rectal dialysis fluid from ten patients with active ulcerative colitis before and after oral administration of 800 mg of the 5-lipoxygenase inhibitor A-64077. The median LTB4 level fell significantly, from 4.9 (range 0.6-20.4) ng/ml before treatment to 1.6 (0.3-5.7) ng/ml after 4 h and 0.7 (0.1-8.0) ng/ml after 8 h; it had returned to pretreatment levels by 28 h. The concentration of PGE2 did not change significantly. The increased generation of 5-lipoxygenase products, such as LTB4, in ulcerative colitis and the potent proinflammatory actions of these products suggest that they have an important role in the amplification of the inflammatory response. A controlled trial to assess the clinical efficacy of A-64077 seems worth while.
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Authors | L S Laursen, J Naesdal, K Bukhave, K Lauritsen, J Rask-Madsen |
Journal | Lancet (London, England)
(Lancet)
Vol. 335
Issue 8691
Pg. 683-5
(Mar 24 1990)
ISSN: 0140-6736 [Print] England |
PMID | 1969061
(Publication Type: Journal Article)
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Chemical References |
- Lipoxygenase Inhibitors
- Leukotriene B4
- Arachidonate Lipoxygenases
- Dinoprostone
- zileuton
- Hydroxyurea
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Arachidonate Lipoxygenases
(antagonists & inhibitors)
- Colitis, Ulcerative
(drug therapy, enzymology)
- Dialysis
- Dinoprostone
(analysis)
- Drug Evaluation
- Humans
- Hydroxyurea
(administration & dosage, analogs & derivatives, therapeutic use)
- Leukotriene B4
(analysis)
- Lipoxygenase Inhibitors
- Middle Aged
- Recurrence
- Time Factors
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