Abstract | BACKGROUND/AIMS: PATIENTS AND METHODS: 43 patients with MPO- ANCA-associated vasculitis, 16 patients with chronic renal failure, 10 patients with sepsis, 15 patients with systemic lupus erythematosus, and 18 healthy controls were enrolled in this study, and the surface expression levels of TNFR1, TNFR2, CD63, and CD64 on granulocytes were assessed. In 21 patients with MPO- ANCA-associated vasculitis, soluble TNFR1 (sTNFR1), soluble TNFR2(sTNFR2), and TNF-alpha in the serum were also measured. RESULTS: The surface expression levels of TNFR1 and TNFR2 on granulocytes were significantly higher in patients with MPO- ANCA-associated vasculitis than in the healthy controls, and positively correlated with the Birmingham Vasculitis Activity Score (BVAS). The levels of sTNFR1, sTNFR2, and TNF-alpha in the serum were also significantly higher in patients with MPO- ANCA-associated vasculitis than in the healthy controls. Serum levels of sTNFR1 and sTNFR2 correlated with serum creatinine, while the surface expression of TNFR1 and TNFR2 on the granulocytes did not. There was no significant correlation between the BVAS and CD63 or BVAS and CD64. CONCLUSION:
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Authors | Midori Hasegawa, Chikako Nishii, Atsushi Ohashi, Makoto Tomita, Shigeru Nakai, Kazutaka Murakami, Kunihiro Nabeshima, Yoshirou Fujita, Junichi Ishii, Yoshiyuki Hiki, Satoshi Sugiyama |
Journal | Nephron. Clinical practice
(Nephron Clin Pract)
Vol. 113
Issue 3
Pg. c222-33
( 2009)
ISSN: 1660-2110 [Electronic] Switzerland |
PMID | 19690440
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
- Autoantibodies
- Biomarkers
- Receptors, Tumor Necrosis Factor
- Peroxidase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
(blood, diagnosis, enzymology)
- Antibodies, Antineutrophil Cytoplasmic
(blood)
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Female
- Gene Expression Regulation
- Granulocytes
(enzymology, metabolism)
- Humans
- Male
- Middle Aged
- Peroxidase
(blood)
- Receptors, Tumor Necrosis Factor
(biosynthesis, blood, genetics)
- Young Adult
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