Olmesartan medoxomil: recent clinical and experimental acquisitions.

Abstract

Angiotensin II is a vasoactive hormone of the renin-angiotensin system and plays an important role in the pathophysiology of several organ damages. Angiotensin II receptor blockers have been shown to be effective in treating both hypertension and connected organ damages. It is well known that although the angiotensin II receptor blockers have structural and pharmacokinetic differences, few pharmacological differences separate them. One of these is the degree of binding to the angiotensin II receptor type 1 compared with the angiotensin II receptor type 2; olmesartan medoxomil exhibits more than a 12,500-fold greater affinity for the angiotensin II receptor type 1 receptor than for the angiotensin II receptor type 2, making it theoretically the second most potent agent. However, olmesartan's excellent receptor interaction is based on the combination of several specific pharmacokinetic factors. Potential advantages of this drug include once-daily dosing, a very low incidence of significant adverse reactions and/or events and a well-tolerated side effect profile. Nowadays, we have a lot of information about the pharmacology, antihypertensive efficacy and safety of olmesartan medoxomil, to further extend many clinical studies are still continuing to evaluate the potential benefits of high dosages and/or combination of this molecule.

• Authors: Maurizio Destro, Paola Preti, Antonio D'Ospina, Ngu Njwe Christian Achiri, Alessandra Rossi Ricci, Francesca Cagnoni
• Journal: Expert opinion on drug metabolism & toxicology (Expert Opin Drug Metab Toxicol) Vol. 5 Issue 9 Pg. 1149-57 (Sep 2009) ISSN: 1744-7607 [Electronic] England
• PMID: 19689219 (Publication Type: Journal Article, Review)

Chemical References

• Antihypertensive Agents
• Imidazoles
• Tetrazoles
• Olmesartan Medoxomil

Topics

• Antihypertensive Agents (adverse effects, pharmacokinetics, therapeutic use)
• Clinical Trials as Topic
• Humans
• Hypertension (drug therapy)
• Imidazoles (adverse effects, pharmacokinetics, therapeutic use)
• Olmesartan Medoxomil
• Tetrazoles (adverse effects, pharmacokinetics, therapeutic use)