Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population.

Abstract

BACKGROUND:

Studies of serotonin reuptake transporter (SERT-P) polymorphism and irritable bowel syndrome (IBS) have shown diverse results among different populations, which might be due to racial and ethnic difference.

AIM:

This study was to investigate the potential association between the SERT-P polymorphism and clinical subtypes of IBS patients in the Indian population.

METHOD:

This prospective case-control study included 151 IBS patients. Ninety-two patients were diarrhea-predominant IBS, 44 were constipation-predominant IBS (C-IBS), 15 were alternating diarrhea and constipation IBS, and 100 were healthy controls. SERT gene polymorphism was studied by polymerase chain reaction.

RESULT:

A genotypic association was observed between SS genotype of SERT-P polymorphism and C-IBS (P<0.05). When the L/S and L/L genotypes were combined into one group, the frequency of the S/S genotype was significantly higher than that of the non-S/S genotype between C-IBS and the control group (P<0.05). There was no significant difference in the SERT-P genotype and allele frequency between c-ibs, alternating diarrhea and constipation IBS, all types of IBS cases, and controls.

CONCLUSIONS:

A significant association was observed between the SS genotype of SERT-P polymorphism and C-IBS in the Indian population.

• Authors: Arbab Sikander, Satya Vati Rana, Saroj Kant Sinha, Kaushal Kishor Prasad, Sunil K Arora, Sanjeev Kumar Sharma, Kartar Singh
• Journal: Journal of clinical gastroenterology (J Clin Gastroenterol) 2009 Nov-Dec Vol. 43 Issue 10 Pg. 957-61 ISSN: 1539-2031 [Electronic] United States
• PMID: 19687750 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• SLC6A4 protein, human
• Serotonin Plasma Membrane Transport Proteins

Topics

• Adult
• Case-Control Studies
• Constipation (etiology)
• Diarrhea (etiology)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• India
• Irritable Bowel Syndrome (ethnology, genetics, physiopathology)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prospective Studies
• Serotonin Plasma Membrane Transport Proteins (genetics)