[An empirical study of treating chronic sinusitis with low dose Roxithromycin].

Abstract

OBJECTIVE:

Observe the therapeutic effect of low dose Roxithromycin in treating chronic sinusitis and further discuss the mechanism of Roxithromycin facile endothelial cell apoptosis.

METHOD:

All 47 patients who suffer chronic sinusitis at out-patient clinic from 2006. 10 to 2008. 03 were administered low dose Roxithromycin. Follow up all the patients and get polypi at 3-month and 6-month. AO/EB was employed to detect the apoptosis of endothelial cell.

RESULT:

At 3-month and 6-month the improvement of ventilation are 37.25 +/- 12.21, 63.15 +/- 22.78; Decrease of nasal discharge are 42.12 +/- 13.56, 74.45 +/- 28.79; alleviation of headache are 18.98 +/- 7. 66, 34.47 +/- 14.11; Improvement of olfactory are 21.23 +/- 8.41, 38.18 +/- 16.54; Apoptotic index are (39.54 +/- 6.86)% and (62.34 +/- 8.67)%, which are significantly different (P<0.05).

CONCLUSION:

Low dose Roxithromycin has good long term curative effect in treating chronic sinusitis. Low dose Roxithromycin can greatly urge the apoptosis of endothelial cell.

• Authors: Yan Song, Weiliang Bai, Wenyue Ji
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 23 Issue 8 Pg. 357-8, 363 (Apr 2009) ISSN: 2096-7993 [Print] China
• PMID: 19685715 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Roxithromycin

Topics

• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Apoptosis
• Child
• Chronic Disease
• Female
• Humans
• Male
• Middle Aged
• Nasal Polyps (complications, drug therapy)
• Roxithromycin (administration & dosage, therapeutic use)
• Sinusitis (complications, drug therapy)
• Young Adult