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Effectiveness of combination use of antibiotic-loaded PerOssal with spinal surgery in patients with spondylodiscitis.

Abstract
Degradable composites of calcium sulphate and nanoparticulate hydroxyapatite (PerOssal) have shown promising results in vitro. Here we investigated the handling, efficacy and compatibility of PerOssal when loaded with gentamicin or vancomycin in 19 patients with spondylodiscitis in vivo. So far, 12 patients who were followed up over at least 1 year have shown a normalization of the infection parameters, no more bone loss in the affected regions and a bony fusion after 3-6 months postoperatively. No revision surgery was related to the use of PerOssal. Locally there were no signs of an ongoing infection. This study demonstrates encouraging results regarding handling, resorption, biocompatibility and antibiotic release using PerOssal pellets in vivo.
AuthorsDietrich von Stechow, M A Rauschmann
JournalEuropean surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes (Eur Surg Res) Vol. 43 Issue 3 Pg. 298-305 ( 2009) ISSN: 1421-9921 [Electronic] Switzerland
PMID19684405 (Publication Type: Clinical Trial, Journal Article)
CopyrightCopyright 2009 S. Karger AG, Basel.
Chemical References
  • Anti-Bacterial Agents
  • Gentamicins
  • Vancomycin
  • Durapatite
  • Calcium Sulfate
Topics
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage)
  • Calcium Sulfate (administration & dosage)
  • Discitis (drug therapy, surgery)
  • Drug Therapy, Combination
  • Durapatite (administration & dosage)
  • Female
  • Gentamicins (administration & dosage)
  • Humans
  • Male
  • Middle Aged
  • Nanoparticles
  • Prospective Studies
  • Treatment Outcome
  • Vancomycin (administration & dosage)

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