Abstract | PURPOSE: MATERIALS AND METHODS: All participants underwent clinical and urodynamic assessment, and completed a quality of life questionnaire before botulinum toxin type A treatment, and 1 and 3 months thereafter. Four patients with Parkinson's disease and 2 with multiple system atrophy were enrolled in the study. All patients received 200 U botulinum toxin type A injected into the detrusor muscle at 20 sites under cystoscopic guidance at a single session on an inpatient basis. Outcome measures were clinical assessment (a voiding diary including daytime and nighttime urinary frequency, and episodes of urgency and urge urinary incontinence), urodynamic assessment (including first volume and maximum pressure of uninhibited detrusor contractions, and maximum cystometric capacity) and pressure flow studies. RESULTS: One and 3 months after botulinum toxin type A injection all patients reported that daytime and nighttime urinary frequency had decreased and quality of life scores improved. No patients had further episodes of urgency and urge urinary incontinence during the 5-month followup. Urodynamics showed improvement in all urinary function variables tested. No systemic side effects were recorded during or after treatment. In all patients post-void urinary residual volume increased and intermittent catheterization was required only in those with multiple system atrophy. CONCLUSIONS:
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Authors | Antonella Giannantoni, Aroldo Rossi, Ettore Mearini, Michele Del Zingaro, Massimo Porena, Alfredo Berardelli |
Journal | The Journal of urology
(J Urol)
Vol. 182
Issue 4
Pg. 1453-7
(Oct 2009)
ISSN: 1527-3792 [Electronic] United States |
PMID | 19683298
(Publication Type: Journal Article)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Botulinum Toxins, Type A
(therapeutic use)
- Female
- Humans
- Multiple System Atrophy
(complications)
- Neuromuscular Agents
(therapeutic use)
- Parkinson Disease
(complications)
- Urinary Bladder, Overactive
(drug therapy, etiology)
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