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Memory performance is related to language dominance as determined by the intracarotid amobarbital procedure.

AbstractOBJECTIVE:
The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.
METHODS:
In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other.
RESULTS:
Language lateralization and memory lateralization were positively correlated (r=0.34, P<0.01). Correlations differed depending on the presence and type of lesion (chi(2)=7.98, P<0.05). LIs correlated significantly higher (z=2.82, P<0.05) in patients with cortical dysplasia (n=41, r=0.61, P<0.01) compared with the group without lesions (n=90, r=0.16, P>0.05), with patients with hippocampal sclerosis falling between these two groups. Both memory (P<0.01) and language (P<0.01) LIs were higher in right- compared with left-sided lesions.
CONCLUSION:
Correlation of language and memory is more pronounced in patients with structural lesions as compared with patients without lesions on MRI.
AuthorsS Kovac, G Möddel, J Reinholz, A V Alexopoulos, T Syed, S U Schuele, T Lineweaver, T Loddenkemper
JournalEpilepsy & behavior : E&B (Epilepsy Behav) Vol. 16 Issue 1 Pg. 145-9 (Sep 2009) ISSN: 1525-5069 [Electronic] United States
PMID19682954 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amobarbital
Topics
  • Adult
  • Amobarbital (administration & dosage)
  • Brain Neoplasms (complications)
  • Carotid Arteries
  • Cerebral Angiography
  • Cerebral Cortex (abnormalities)
  • Epilepsy (classification, etiology, physiopathology)
  • Executive Function (physiology)
  • Female
  • Functional Laterality (physiology)
  • Hippocampus (pathology)
  • Humans
  • Injections, Intra-Arterial
  • Intracranial Arteriovenous Malformations (complications)
  • Language
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Male
  • Memory (physiology)
  • Psychomotor Performance (physiology)
  • Retrospective Studies
  • Sclerosis

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