Abstract | OBJECTIVE: The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure. METHODS: In 386 patients, language lateralization and memory lateralization as determined by laterality index (LI) were correlated with each other. RESULTS: Language lateralization and memory lateralization were positively correlated (r=0.34, P<0.01). Correlations differed depending on the presence and type of lesion (chi(2)=7.98, P<0.05). LIs correlated significantly higher (z=2.82, P<0.05) in patients with cortical dysplasia (n=41, r=0.61, P<0.01) compared with the group without lesions (n=90, r=0.16, P>0.05), with patients with hippocampal sclerosis falling between these two groups. Both memory (P<0.01) and language (P<0.01) LIs were higher in right- compared with left-sided lesions. CONCLUSION: Correlation of language and memory is more pronounced in patients with structural lesions as compared with patients without lesions on MRI.
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Authors | S Kovac, G Möddel, J Reinholz, A V Alexopoulos, T Syed, S U Schuele, T Lineweaver, T Loddenkemper |
Journal | Epilepsy & behavior : E&B
(Epilepsy Behav)
Vol. 16
Issue 1
Pg. 145-9
(Sep 2009)
ISSN: 1525-5069 [Electronic] United States |
PMID | 19682954
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Amobarbital
(administration & dosage)
- Brain Neoplasms
(complications)
- Carotid Arteries
- Cerebral Angiography
- Cerebral Cortex
(abnormalities)
- Epilepsy
(classification, etiology, physiopathology)
- Executive Function
(physiology)
- Female
- Functional Laterality
(physiology)
- Hippocampus
(pathology)
- Humans
- Injections, Intra-Arterial
- Intracranial Arteriovenous Malformations
(complications)
- Language
- Magnetic Resonance Angiography
- Magnetic Resonance Imaging
- Male
- Memory
(physiology)
- Psychomotor Performance
(physiology)
- Retrospective Studies
- Sclerosis
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