Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years.

Abstract

Antiepileptic drugs (AEDs) remain a first treatment approach in Landau-Kleffner syndrome (LKS) and related syndromes. In the current literature, only class IV evidence is available. Inclusion criteria and outcome parameters are ill-defined. Most commonly, valproate, ethosuximide, and/or benzodiazepines are used. More recent case series show that sulthiame and especially levetiracetam can be considered as effective drugs. Smaller studies also point to the ketogenic diet as a valuable treatment option in LKS.

• Authors: Lieven Lagae
• Journal: Epilepsia (Epilepsia) Vol. 50 Suppl 7 Pg. 59-62 (Aug 2009) ISSN: 1528-1167 [Electronic] United States
• PMID: 19682054 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Immunoglobulins, Intravenous
• Benzodiazepines
• Ethosuximide
• Valproic Acid

Topics

• Anticonvulsants (therapeutic use)
• Behavior Therapy
• Benzodiazepines (therapeutic use)
• Child
• Combined Modality Therapy
• Diet, Ketogenic (methods)
• Electroencephalography (statistics & numerical data)
• Epilepsies, Partial (diet therapy, drug therapy)
• Ethosuximide (therapeutic use)
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Landau-Kleffner Syndrome (diet therapy, drug therapy)
• Sleep (physiology)
• Speech Therapy
• Status Epilepticus (diet therapy, drug therapy)
• Valproic Acid (therapeutic use)