Increased oxidized low density lipoprotein associated with high ceruloplasmin activity in patients with active acromegaly.

Abstract

OBJECTIVE:

Active acromegaly is associated with increased mortality from cardiovascular causes. Several studies have shown increased atherogenic risk factors and biomarkers of inflammation and atherosclerosis in association with growth hormone excess. The aim of this study was to evaluate oxidized low density lipoprotein (oxLDL) levels and some modulators of LDL oxidative modification in patients with acromegaly.

DESIGN:

Open transversal study.

PATIENTS:

Fifteen patients with active acromegaly and 15 controls were studied.

MEASUREMENTS:

We evaluated the levels of oxLDL, thiobarbituric acid reactive substances (TBARS), ceruloplasmin, bilirubin, uric acid and total reactive antioxidant potential, and the activities of ceruloplasmin, myeloperoxidase, superoxide distmutase, paraoxonase 1, and platelet activating factor acethylhydrolase. Statistical analysis was performed including body mass index as a covariate or as a fixed variable.

RESULTS:

Patients with acromegaly showed significantly higher levels of oxLDL (120 +/- 19 vs. 86 +/- 20 U/l, P < 0.001) and endothelin (P < 0.05), increased ceruloplasmin activity (P < 0.01) and a trend towards higher values in TBARS concentration (P = 0.07) in comparison to healthy controls. OxLDL was positively associated with GH, IGF-I and its binding protein 3 (r = 0.63, P < 0.001; r = 0.53, P < 0.01; and r = 0.56, P < 0.01; respectively). OxLDL showed direct associations with endothelin-1 (r = 0.53, P < 0.01) and ceruloplasmin activity (r = 0.43, P < 0.05). The other parameters evaluated were similar in both groups.

CONCLUSIONS:

The increase in plasma oxLDL levels, a direct marker of the plaque formation, could constitute a link between atherosclerosis and active acromegaly. LDL oxidation would not be the consequence of diminished antioxidant defences, but of an enhancement in prooxidant factors like ceruloplasmin.

• Authors: L Boero, L Cuniberti, N Magnani, M Manavela, V Yapur, M Bustos, L Gómez Rosso, T Meroño, L Marziali, L Viale, P Evelson, G Negri, F Brites
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 72 Issue 5 Pg. 654-60 (May 2010) ISSN: 1365-2265 [Electronic] England
• PMID: 19681912 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endothelin-1
• Insulin-Like Growth Factor Binding Protein 3
• Lipoproteins, LDL
• Thiobarbituric Acid Reactive Substances
• oxidized low density lipoprotein
• Human Growth Hormone
• Uric Acid
• Insulin-Like Growth Factor I
• Peroxidase
• Superoxide Dismutase
• Ceruloplasmin
• 1-Alkyl-2-acetylglycerophosphocholine Esterase
• Bilirubin

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (blood)
• Acromegaly (blood, metabolism, pathology)
• Adult
• Aged
• Aged, 80 and over
• Bilirubin (blood)
• Body Mass Index
• Ceruloplasmin (analysis)
• Endothelin-1 (blood)
• Female
• Human Growth Hormone (blood, metabolism)
• Humans
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (analysis)
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Multivariate Analysis
• Peroxidase (blood)
• Superoxide Dismutase (blood)
• Thiobarbituric Acid Reactive Substances (analysis)
• Uric Acid (blood)