Rhabdomyolysis developing after transcatheter arterial chemoembolization for hepatocellular carcinoma.

Abstract

A 25-year-old man with hepatocellular carcinoma developed severe muscular weakness and pain 15 days after transcatheter arterial chemoembolization (TACE). The diagnosis of rhabdomyolysis was made based on myalgia localized in the bilateral upper extremities (bilateral trapezius, deltoid, biceps brachii, and teres major muscles) on magnetic resonance imaging and increased levels of muscle-derived serum enzymes. In this case, some drugs administered during the clinical course of TACE (diclofenac, famotidine, and cefotiam dihydrochloride) were suspected to be involved in the rhabdomyolysis, but the exact cause of rhabdomyolysis was not identified. The symptoms were completely improved by right trisegmentectomy of the liver following conservative treatment.

• Authors: Kunishige Matake, Tsuyoshi Tajima, Kengo Yoshimitsu, Hiroyuki Irie, Hitoshi Aibe, Atsushi Sugitani, Hiroshi Honda
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 32 Issue 6 Pg. 1284-7 (Nov 2009) ISSN: 1432-086X [Electronic] United States
• PMID: 19680719 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Carcinoma, Hepatocellular (therapy)
• Chemoembolization, Therapeutic (adverse effects)
• Humans
• Liver Neoplasms (therapy)
• Magnetic Resonance Imaging
• Male
• Rhabdomyolysis (diagnosis, etiology)