Abstract | PURPOSE: METHODS: VNR and DXR were diluted with normal saline to prepare test solutions at concentrations of 0.6 mg/mL and 1.4 mg/mL, respectively. Each test solution was infused into the auricular veins of rabbits. Two days after VNR infusion and three days after DXR infusion, the veins were evaluated histopathologically. The effect of DEX on VNR-induced phlebitis was evaluated by infusion of DEX before or after VNR. The effect of PSL on DXR-induced phlebitis was similarly evaluated by co-infusion of PSL. RESULTS: The histopathological features of phlebitis caused by the antineoplastic agents differed between VNR and DXR: VNR did not cause the loss of venous endothelial cells, but caused inflammatory cell infiltration, edema, and epidermal degeneration. In contrast, DXR caused the loss of venous endothelial cells and chrondrocyte necrosis. Pre-treatment and post-treatment with DEX significantly decreased VNR-induced phlebitis compared with the control group and pre-treatment was particularly effective. Co-infusion of PSL also significantly decreased phlebitis caused by DXR, but its effect was less marked. CONCLUSION: The present findings suggested that pre-treatment with DEX may be a useful method for preventing phlebitis due to VNR, and that co-infusion of PSL has the potential to prevent phlebitis caused by DXR.
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Authors | Emiko Kohno, Saori Murase, Kenji Matsuyama, Noboru Okamura |
Journal | International journal of medical sciences
(Int J Med Sci)
Vol. 6
Issue 5
Pg. 218-23
(Aug 06 2009)
ISSN: 1449-1907 [Electronic] Australia |
PMID | 19680474
(Publication Type: Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Antineoplastic Agents
- Vinblastine
- Dexamethasone
- Doxorubicin
- Prednisolone
- Vinorelbine
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Animals
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Dexamethasone
(administration & dosage, therapeutic use)
- Disease Models, Animal
- Doxorubicin
(administration & dosage, adverse effects)
- Infusions, Intravenous
- Male
- Phlebitis
(chemically induced, drug therapy, pathology, prevention & control)
- Prednisolone
(administration & dosage, therapeutic use)
- Rabbits
- Vinblastine
(administration & dosage, adverse effects, analogs & derivatives)
- Vinorelbine
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