[Effects of mangesium salts and their combinations with vitamin B6 on oxalates crystalluria in rats fed with pyridoxine-deficient diet].

Abstract

We studied the effects of oral magnesium (Mg) salts either alone or in combination with pyridoxine hydrochloride in rats on pyridoxine-deficient diet. Fifty-four male rats were randomized into two groups and were fed either a standard diet or a pyridoxine-deficient diet for 3 weeks. A significant rise of the EGOT index ( > 1.5), oxaluria (from 74.8 +/- 5.2 to 117.9 +/- 12.3 mcM/l, p = 0.035), and crystalluria in rats fed with pyridoxine deficient diet were revealed. Oral Mg chloride, Mg L-aspartate either alone or in combination with pyridoxine in comparison with magnesium sulfate, magne B6 (Mg lactate with pyridoxine) and pyridoxine alone were administered (50 mg of magnesium and/or 5 mg of pyridoxine per kg body weight). Magnesium salts in combination with pyridoxine lowered an oxalate level and crystalluria whereas magnesium salts alone reduced only crystalluria. Antilithis effects of Mg L-aspartate and Mg chloride in combination with pyridoxine were comparable with those observed in magne B6 or pyridoxine treatment and were significantly higher than in magnesium sulfate treatment.

• Authors: A A Spasov, I N Iezhitsa, M V Kharitonova, M S Kravchenko
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2009 May-Jun Issue 3 Pg. 22-5 ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 19670811 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Magnesium Compounds
• Oxalates
• Magnesium Chloride
• Aspartic Acid
• Magnesium Sulfate
• Aspartate Aminotransferases
• Magnesium
• Pyridoxine

Topics

• Animals
• Aspartate Aminotransferases (metabolism)
• Aspartic Acid (administration & dosage, pharmacokinetics, therapeutic use)
• Crystallization
• Diet
• Disease Models, Animal
• Drug Therapy, Combination
• Erythrocytes (enzymology)
• Hyperoxaluria (blood, etiology, prevention & control, urine)
• Magnesium (blood, urine)
• Magnesium Chloride (administration & dosage, pharmacokinetics, therapeutic use)
• Magnesium Compounds (administration & dosage, pharmacokinetics, therapeutic use)
• Magnesium Sulfate (administration & dosage, pharmacokinetics, therapeutic use)
• Male
• Oxalates (urine)
• Pyridoxine (administration & dosage, deficiency, therapeutic use)
• Rats
• Treatment Outcome