Dideoxycytidine toxicity on mouse hemopoietic progenitors.

Abstract

Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2', 3' Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Results reported here show a toxic activity of ddc but further studies are required to ascertain whether this toxicity is of significance during clinical application.

• Authors: M Mencoboni, R Lerza, G Bogliolo, G Flego, L Gasparini, I Pannacciulli
• Journal: In vivo (Athens, Greece) (In Vivo) 1990 May-Jun Vol. 4 Issue 3 Pg. 171-3 ISSN: 0258-851X [Print] Greece
• PMID: 1966801 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Zalcitabine

Topics

• Animals
• Bone Marrow (drug effects, pathology)
• Colony-Forming Units Assay
• Female
• Hematopoiesis (drug effects)
• Hematopoietic Stem Cells (drug effects)
• Male
• Mice
• Mice, Inbred DBA
• Pancytopenia (chemically induced)
• Zalcitabine (pharmacology, toxicity)