Abstract | PURPOSE: PATIENTS AND METHODS: Serum samples were obtained and cardiac ultrasound studies performed in 102 NET patients. The criterion for mild and severe CHD was tricuspid regurgitation stage I/II and III/IV, respectively. Proportional odds and Cox proportional hazards models were constructed respectively to identify the association between CHD and overall survival with patient characteristics and the two markers. RESULTS: Severe CHD was found in 15 (15%) of 102 patients, 13 of whom had elevated NT-proBNP levels. In the univariate proportional odds model CHD was correlated with age (P = .007), CgA (P = .002), and NT-proBNP (P < .001), whereas in the multivariate model NT-proBNP and CgA were significantly associated with CHD (P < .001 and P = .01). In the univariate Cox models, age (P = .04), sex (P = .03), CgA (P = .003), and NT-proBNP (P = .04) were related to overall survival, and in the multivariate model CgA and NT-proBNP remained significantly related to overall survival (P = .002 and P = .04, respectively). CONCLUSION:
NT-proBNP and CgA are very important markers in the diagnosis of CHD in patients with NET. Furthermore, patients with elevated NT-proBNP in addition to elevated CgA levels showed worse overall survival than patients with elevated CgA alone.
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Authors | Catharina M Korse, Babs G Taal, Cornelis A de Groot, Robert H Bakker, Johannes M G Bonfrer |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 27
Issue 26
Pg. 4293-9
(Sep 10 2009)
ISSN: 1527-7755 [Electronic] United States |
PMID | 19667278
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Chromogranin A
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Biomarkers
(blood)
- Carcinoid Heart Disease
(blood, diagnosis)
- Chromogranin A
(blood)
- Female
- Humans
- Immunoradiometric Assay
(statistics & numerical data)
- Male
- Middle Aged
- Multivariate Analysis
- Natriuretic Peptide, Brain
(blood)
- Neuroendocrine Tumors
(blood, diagnosis)
- Peptide Fragments
(blood)
- Predictive Value of Tests
- Proportional Hazards Models
- Sensitivity and Specificity
- Survival Analysis
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