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Expression of the porcine transmissible gastroenteritis coronavirus M protein.

Abstract
Cloned cDNA encoding the M protein of the porcine transmissible gastroenteritis coronavirus (TGEV) was introduced into a vaccinia virus to examine the function of the amino-terminal signal peptide. The M protein expressed by the recombinant virus was targeted to the Golgi region of infected cells, as is the M protein in cells infected with TGEV. The protein appeared not to undergo processing other than glycosylation. However, the vaccinia-expressed M protein was slightly larger than the protein found in TGEV-infected cells, suggesting that a difference in modification exists between the proteins.
AuthorsB G Hogue, D P Nayak
JournalAdvances in experimental medicine and biology (Adv Exp Med Biol) Vol. 276 Pg. 121-6 ( 1990) ISSN: 0065-2598 [Print] United States
PMID1966402 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Protein Sorting Signals
  • Viral Matrix Proteins
Topics
  • Animals
  • Cells, Cultured
  • Cloning, Molecular
  • Gene Expression
  • Genes, Viral
  • Male
  • Molecular Weight
  • Protein Sorting Signals (genetics)
  • Restriction Mapping
  • Swine
  • Testis
  • Transmissible gastroenteritis virus (genetics)
  • Vaccinia virus (genetics)
  • Viral Matrix Proteins (biosynthesis, genetics, isolation & purification)

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