Necrobiotic xanthogranuloma without paraproteinaemia: marked improvement with psoralen ultraviolet A treatment.

Abstract

Necrobiotic xanthogranuloma (NXG) is a rare granulomatous condition that is often associated with a paraproteinaemia and in some cases multiple myeloma. Treatment is therefore aimed at the underlying associated haematological abnormality. However, isolated NXG cases have been reported. We report a case of isolated NXG that responded very well to systemic psoralen ultraviolet A (PUVA) treatment. The rationale for this treatment was the successful use of PUVA treatment in other necrobiotic conditions such as granuloma annulare and necrobiosis lipoidica.

• Authors: F A Al-Niaimi, G Dawn, N H Cox
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 35 Issue 3 Pg. 275-7 (Apr 2010) ISSN: 1365-2230 [Electronic] England
• PMID: 19663852 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Diagnosis, Differential
• Humans
• Male
• Necrobiotic Disorders (drug therapy, pathology)
• PUVA Therapy (methods)
• Treatment Outcome
• Xanthomatosis (drug therapy, pathology)