MRSA-pyomyositis in a patient with acute myelogenous leukemia after intensive chemotherapy.

Abstract

BACKGROUND:

A case of methicillin-resistant Staphylococcus aureus (MRSA)-pyomyositis in association with acute myelogenous leukemia (AML) is reported. MRSA-sepsis developed in a 51-year-old Japanese man with AML, during the neutropenic period after high-dose 1-beta-d-arabinofuranosylcytosine (Ara-C). Although the MRSA-sepsis initially improved with arbekacin sulfate (ABK) administration, a high fever recurred with left thigh pain despite recovery of the neutrophil count after ABK was stopped. A computed tomographic (CT) scan showed a low-density area in the left quadriceps femoris muscle, which led to a diagnosis of pyomyositis. MRSA was cultured from the abscess aspirates. The fever and thigh pain disappeared after administration of ABK and minocycline hydrochloride (MINO), and the abscess completely disappeared with the oral administration of levofloxacin (LVFX) for about 3 months.

CONCLUSION:

If an immunocompromised patient complains of fever and muscle pain after intensive chemotherapy, MRSA-pyomyositis should be considered.

• Authors: Toshihiro Fukushima, Haruka Iwao, Akio Nakazima, Miyuki Miki, Tomoyuki Sakai, Toshioki Sawaki, Masao Tanaka, Yasufumi Masaki, Yuko Hirose, Hisanori Umehara
• Journal: Anticancer research (Anticancer Res) Vol. 29 Issue 8 Pg. 3361-4 (Aug 2009) ISSN: 1791-7530 [Electronic] Greece
• PMID: 19661356 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents
• Dibekacin
• arbekacin

Topics

• Abscess (diagnosis, drug therapy, etiology)
• Anti-Infective Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Dibekacin (analogs & derivatives, therapeutic use)
• Fever (prevention & control)
• Humans
• Immunocompromised Host
• Leukemia, Myeloid, Acute (complications, drug therapy, microbiology)
• Male
• Methicillin Resistance
• Methicillin-Resistant Staphylococcus aureus (pathogenicity)
• Middle Aged
• Pyomyositis (diagnosis, drug therapy, etiology)
• Remission Induction
• Staphylococcal Infections (diagnosis, drug therapy, etiology)