[Phonophoresis of the proteolytic enzymes lekozim or kollalizin in the combined therapy of eye burns].

Abstract

A two-stage phonophoresis of proteolytic enzymes of lecozim or collalysine was used in a complex treatment of severe eye burns. The main group of patients consisted of 20 patients (23 eyes) treated by lecozim phonophoresis and 6 patients (6 eyes)--by collalysine phonophoresis. The control group consisted of 23 patients (25 eyes) treated by a complex treatment without phonophoresis of proteolytic enzymes. The comparative analysis of the course of a burn disease in both groups has shown positive influence of enzyme therapy on its dynamics and outcome. In the main group, the arrest of inflammatory signs accomplished earlier (by the 27th-29th day) as compared with the control group (by the 32nd-38th day) as well as epithelialization of corneal defects (by the 27th-30th day and by the 34th-42nd day, respectively); earlier vascularization of the cornea stimulated improvement of the burn process. Of a characteristic feature of the treatment was resolution of corneal opacification that began already after the first stage and continued within the second stage of the treatment. This allowed to achieve higher functional results. In the main group, visual acuity rose in 88.5%, and in the control--in 48% of patients.

• Authors: S A Iakimenko, R I Chalanova
• Journal: Oftalmologicheskii zhurnal (Oftalmol Zh) Issue 6 Pg. 321-4 ( 1990) ISSN: 0030-0675 [Print] Ukraine
• Vernacular Title: Fonoforez proteoliticheskikh fermentov lekozima ili kollalizina v kompleksnoĭ terapii ozhogov glaz.
• PMID: 1966113 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• lekozim
• Peptide Hydrolases
• Papain
• Chymopapain
• Microbial Collagenase

Topics

• Chymopapain (administration & dosage)
• Combined Modality Therapy
• Drug Combinations
• Drug Evaluation
• Eye Burns (drug therapy, physiopathology)
• Humans
• Microbial Collagenase (administration & dosage)
• Papain (administration & dosage)
• Peptide Hydrolases (administration & dosage)
• Phonophoresis (methods)
• Time Factors
• Visual Acuity (drug effects)
• Wound Healing (drug effects)