Abstract | OBJECTIVE: This study investigates the cardioprotective role and mechanism of action of urocortin in patients undergoing cardiac surgery, with respect to protein kinase Cepsilon expression, activation, and relocation. BACKGROUND: METHODS: Two sequential biopsies were obtained from the right atrium of 25 patients undergoing coronary artery bypass grafting at the start of grafting (internal control) and 10 minutes after release of the aortic clamp. RESULTS: CONCLUSION:
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Authors | Carol Chen-Scarabelli, Giuseppe Faggian, Zhaokan Yuan, Maddalena Tessari, Alessio Rungatscher, Justin Di Rezze, Gabriele M Scarabelli, Kadija Abounit, Roy McCauley, Louis Saravolatz, Alessandro Mazzucco, Tiziano M Scarabelli |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 138
Issue 5
Pg. 1213-21
(Nov 2009)
ISSN: 1097-685X [Electronic] United States |
PMID | 19660384
(Publication Type: Journal Article)
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Chemical References |
- RNA, Messenger
- Urocortins
- Protein Kinase C
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Topics |
- Aged
- Analysis of Variance
- Apoptosis
- Biopsy
- Blotting, Western
- Coronary Artery Bypass
- Female
- Heart Arrest, Induced
(methods)
- Humans
- Iatrogenic Disease
- Immunohistochemistry
- Immunoprecipitation
- Male
- Middle Aged
- Mitochondria, Heart
(physiology)
- Myocardial Ischemia
(metabolism)
- Myocardium
(cytology, metabolism)
- Polymerase Chain Reaction
- Protein Kinase C
(metabolism)
- RNA, Messenger
(metabolism)
- Reperfusion Injury
(metabolism)
- Temperature
- Urocortins
(biosynthesis)
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