Abstract | AIMS: METHODS: RESULTS: CONCLUSIONS: High expression rate of p-mTOR in poorly differentiated neuroendocrine carcinomas (large-cell type) may suggest the potential role of mTOR inhibitors as effective therapeutic agents for this highly malignant disease.
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Authors | Takashi Shida, Takashi Kishimoto, Mitsuko Furuya, Takashi Nikaido, Keiji Koda, Shigetsugu Takano, Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Masayuki Ohtsuka, Tohru Tanizawa, Yukio Nakatani, Masaru Miyazaki |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 65
Issue 5
Pg. 889-93
(Apr 2010)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 19657638
(Publication Type: Journal Article)
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Chemical References |
- Intracellular Signaling Peptides and Proteins
- MTOR protein, human
- Protein Serine-Threonine Kinases
- TOR Serine-Threonine Kinases
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Large Cell
(metabolism)
- Carcinoma, Neuroendocrine
(metabolism)
- Carcinoma, Small Cell
(metabolism)
- Female
- Gastrointestinal Neoplasms
(metabolism)
- Humans
- Intracellular Signaling Peptides and Proteins
(metabolism)
- Male
- Middle Aged
- Pancreatic Neoplasms
(metabolism)
- Protein Serine-Threonine Kinases
(metabolism)
- TOR Serine-Threonine Kinases
- Young Adult
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