Abstract | PURPOSE: To determine the influence of topical vancomycin prophylaxis on the incidence of bacterial endophthalmitis in eyes with a Boston Keratoprosthesis (KPro). METHODS: RESULTS: The 255 eyes were followed for 673.6 patient-years (mean, 2.64 years; range, 1 week to 13 years). There were 18 cases of bacterial endophthalmitis; 17 occurred at least 6 weeks postoperatively (range, 1.5 to 46 months). Gram-positive cocci caused over 80% of cases. Only 1 case, due to an atypical mycobacterium, occurred in a patient using vancomycin.The incidence of bacterial endophthalmitis was lower in the vancomycin group than in the no- vancomycin group: 0.35% versus 4.13% per patient-year (P = 0.001). It was also lower in SJS eyes using vancomycin versus no vancomycin: 1.76% versus 18.39% per patient-year (P = 0.009). In eyes with preoperative diagnoses of burn, OCP, or graft failure/other, the incidence in the vancomycin group was zero. CONCLUSION:
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Authors | Marlene L Durand, Claes H Dohlman |
Journal | Cornea
(Cornea)
Vol. 28
Issue 8
Pg. 896-901
(Sep 2009)
ISSN: 1536-4798 [Electronic] United States |
PMID | 19654525
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Vancomycin
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Antibiotic Prophylaxis
- Bacterial Infections
(epidemiology, prevention & control)
- Cicatrix
(surgery)
- Cornea
(surgery)
- Corneal Transplantation
- Endophthalmitis
(epidemiology, microbiology, prevention & control)
- Equipment Design
- Eye Burns
(surgery)
- Eye Diseases
(surgery)
- Follow-Up Studies
- Graft Rejection
(surgery)
- Gram-Positive Bacterial Infections
(epidemiology)
- Gram-Positive Cocci
- Humans
- Incidence
- Mycobacterium Infections, Nontuberculous
(epidemiology)
- Pemphigoid, Benign Mucous Membrane
(surgery)
- Prosthesis Implantation
- Prosthesis-Related Infections
(epidemiology, prevention & control)
- Retrospective Studies
- Stevens-Johnson Syndrome
(surgery)
- Time Factors
- Treatment Outcome
- Vancomycin
(therapeutic use)
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