Addison's disease induced by miliary tuberculosis and the administration of rifampicin.

Abstract

We herein report a rare occurrence of Addison's disease caused by acute adrenal gland tuberculosis occurring in association with miliary tuberculosis and the administration of rifampicin. An 82-year-old woman with miliary tuberculosis was treated with antituberculous chemotherapeutic agents including rifampicin (RFP), but she still demonstrated general malaise in addition to hyponatremia. Abdominal CT showed an enlargement of the right adrenal gland. However, after discontinuing RFP, the patient's symptoms improved. We carefully reinitiated the administration of RFP. The patient's condition thereafter did not worsen, and the treatment could thus be maintained. It is extremely important to immediately recognize adrenal crisis precipitated by the administration of RFP.

• Authors: Toshinobu Yokoyama, Reiko Toda, Yoshizo Kimura, Makiko Mikagi, Hisamichi Aizawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 48 Issue 15 Pg. 1297-300 ( 2009) ISSN: 1349-7235 [Electronic] Japan
• PMID: 19652434 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antitubercular
• Rifampin

Topics

• Acute Disease
• Addison Disease (diagnosis, etiology)
• Adrenal Gland Diseases (complications, diagnosis, drug therapy)
• Aged
• Aged, 80 and over
• Antibiotics, Antitubercular (administration & dosage, adverse effects)
• Female
• Humans
• Rifampin (administration & dosage, adverse effects)
• Tomography, X-Ray Computed
• Tuberculosis, Endocrine (complications, diagnosis, drug therapy)
• Tuberculosis, Miliary (complications, diagnosis, drug therapy)