Abstract | OBJECTIVE: Current research has focused upon the potential links between novel markers of vascular risk such as endothelial dysfunction, oxidative stress, inflammation and insulin resistance in the pathogenesis of Type 2 diabetes and its complications. Grape seed extract (GSE), a flavonoid-rich product, is a potential moderator of these markers. This study aimed to test the hypothesis that GSE may improve these markers in high-risk cardiovascular subjects with Type 2 diabetes. RESEARCH DESIGN AND METHODS: RESULTS: Baseline characteristics (16 male and 16 female): age 61.8 +/- 6.36 years; body mass index 30.2 +/- 5.92 kg/m2; diabetes duration 5.9 +/- 2.14 years. Following GSE (but not placebo), significant changes were noted in fructosamine (282 +/- 40.9 vs. 273 +/- 50.2 mmol/l; P = 0.0004); whole blood GSH (2359 +/- 823 vs. 3595 +/- 1051 mmol/l; P < 0.01) and hsCRP (3.2 +/- 3.65 vs. 2.0 +/- 2.2 mg/l; P = 0.0006). Total cholesterol concentration also decreased (4.5 +/- 0.96 vs. 4.3 +/- 0.99 mmol/l; P = 0.05). No statistically significant changes were shown in endothelial function, HOMA-IR or TAOS. CONCLUSION: GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk.
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Authors | P Kar, D Laight, H K Rooprai, K M Shaw, M Cummings |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 26
Issue 5
Pg. 526-31
(May 2009)
ISSN: 1464-5491 [Electronic] England |
PMID | 19646193
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- Grape Seed Extract
- Placebos
- Fructosamine
- C-Reactive Protein
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Topics |
- Aged
- Albuminuria
- Biomarkers
(metabolism)
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(etiology, metabolism)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Double-Blind Method
- Endothelium, Vascular
(drug effects)
- Female
- Fructosamine
(metabolism)
- Grape Seed Extract
(pharmacology, therapeutic use)
- Humans
- Insulin Resistance
(physiology)
- Male
- Middle Aged
- Obesity
(complications)
- Oxidative Stress
(drug effects)
- Photoplethysmography
- Placebos
- Risk Factors
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