Abstract | BACKGROUND: HYPOTHESIS:
Ketonemia measurement using a portable meter is more accurate than ketonuria determination with a dipstick to diagnose canine DKA. ANIMALS: METHODS: Prospective observational study. Based on blood bicarbonate concentration and anion gap, dogs were divided into 2 groups: patients with DKA (n= 25); patients with diabetic ketosis (n= 47). Sensitivity, specificity, and positive and negative likelihood ratio (LR) at different cut-off points were determined for both ketonemia and ketonuria. Receiver operating characteristic (ROC) analysis was used to assess the accuracy of each diagnostic test to diagnose DKA. RESULTS: With regard to ketonemia, cut-off values of 2.3 and 4.3 mmol/L revealed 100% sensitivity and 100% specificity, respectively, whereas cut-off values of 2.8 and 3.5 mmol/L showed a -LR of 0.05 and a + LR of 13.16, respectively. With regard to ketonuria, a cut-off value of 1+ revealed 92% sensitivity, 40% specificity, and -LR of 0.20, whereas a cut-off value of 3+ revealed 44% sensitivity, 94% specificity, and +LR of 6.89. The areas under the ROC curves for the ketonemia and ketonuria tests were significantly different (0.97 and 0.81, respectively, P= .003). CONCLUSIONS AND CLINICAL IMPORTANCE: Measurement of ketonemia is accurate and more effective than measurement of ketonuria to diagnose canine DKA.
|
Authors | M Di Tommaso, G Aste, F Rocconi, C Guglielmini, A Boari |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2009 May-Jun
Vol. 23
Issue 3
Pg. 466-71
ISSN: 0891-6640 [Print] United States |
PMID | 19645834
(Publication Type: Evaluation Study, Journal Article)
|
Chemical References |
- Ketones
- 3-Hydroxybutyric Acid
|
Topics |
- 3-Hydroxybutyric Acid
(blood)
- Animals
- Diabetic Ketoacidosis
(blood, diagnosis, urine, veterinary)
- Dog Diseases
(blood, diagnosis)
- Dogs
- Female
- Ketones
(blood, urine)
- Male
- Point-of-Care Systems
- Sensitivity and Specificity
|