HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluation of a portable meter to measure ketonemia and comparison with ketonuria for the diagnosis of canine diabetic ketoacidosis.

AbstractBACKGROUND:
The diagnosis of canine diabetic ketoacidosis (DKA) usually is based on measurement of urinary acetoacetate (ketonuria). In humans, this test is less sensitive and specific than blood 3-beta-hydroxybutyrate (ketonemia) evaluation.
HYPOTHESIS:
Ketonemia measurement using a portable meter is more accurate than ketonuria determination with a dipstick to diagnose canine DKA.
ANIMALS:
Seventy-two client-owned diabetic dogs with ketonemia, ketonuria, or both.
METHODS:
Prospective observational study. Based on blood bicarbonate concentration and anion gap, dogs were divided into 2 groups: patients with DKA (n= 25); patients with diabetic ketosis (n= 47). Sensitivity, specificity, and positive and negative likelihood ratio (LR) at different cut-off points were determined for both ketonemia and ketonuria. Receiver operating characteristic (ROC) analysis was used to assess the accuracy of each diagnostic test to diagnose DKA.
RESULTS:
With regard to ketonemia, cut-off values of 2.3 and 4.3 mmol/L revealed 100% sensitivity and 100% specificity, respectively, whereas cut-off values of 2.8 and 3.5 mmol/L showed a -LR of 0.05 and a + LR of 13.16, respectively. With regard to ketonuria, a cut-off value of 1+ revealed 92% sensitivity, 40% specificity, and -LR of 0.20, whereas a cut-off value of 3+ revealed 44% sensitivity, 94% specificity, and +LR of 6.89. The areas under the ROC curves for the ketonemia and ketonuria tests were significantly different (0.97 and 0.81, respectively, P= .003).
CONCLUSIONS AND CLINICAL IMPORTANCE:
Measurement of ketonemia is accurate and more effective than measurement of ketonuria to diagnose canine DKA.
AuthorsM Di Tommaso, G Aste, F Rocconi, C Guglielmini, A Boari
JournalJournal of veterinary internal medicine (J Vet Intern Med) 2009 May-Jun Vol. 23 Issue 3 Pg. 466-71 ISSN: 0891-6640 [Print] United States
PMID19645834 (Publication Type: Evaluation Study, Journal Article)
Chemical References
  • Ketones
  • 3-Hydroxybutyric Acid
Topics
  • 3-Hydroxybutyric Acid (blood)
  • Animals
  • Diabetic Ketoacidosis (blood, diagnosis, urine, veterinary)
  • Dog Diseases (blood, diagnosis)
  • Dogs
  • Female
  • Ketones (blood, urine)
  • Male
  • Point-of-Care Systems
  • Sensitivity and Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: