Abstract | BACKGROUND AND PURPOSE: To chart remaining complaints 1 year after treatment for neuroborreliosis, and to identify risk factors for a non-favorable outcome. METHODS: We followed patients treated for neuroborreliosis prospectively, and assessed outcome by a composite clinical score. The impact on outcome of clinical, demographic and laboratory factors were analyzed by univariate analyses and logistic regression. RESULTS: Out of 85 patients 41 (48%) had remaining complaints; 14 had objective findings and 27 subjective symptoms. Remaining complaints were associated with pre-treatment symptom duration >or=6 weeks (OR = 4.062, P = 0.044), high pre-treatment cerebrospinal fluid (CSF) cell count (OR = 1.005, P = 0.001), and female gender (OR = 3.218, P = 0.025). Presence of CSF oligoclonal bands (OCBs) was not analyzed in the logistic regression model due to many missing observations, but was found to be more frequent both pre-treatment (P = 0.004) and after 12 months (P = 0.015) among patients with remaining complaints as compared to patients with complete recovery. Further evaluation showed that objective remaining findings, and not subjective symptoms, were associated with pre-treatment symptom duration >or=6 weeks. No difference in outcome was observed between patients treated with IV ceftriaxone and patients treated with oral doxycycline. CONCLUSION: Remaining complaints are common after neuroborreliosis. The majority of the complaints are subjective. Pre-treatment symptom duration >or=6 weeks, high pre-treatment CSF cell count, and female gender seem to be risk factors for remaining complaints. Presence of CSF OCBs may also predict a non-favorable outcome, but this should be further studied. Whether subjective and objective complaints are associated with different risk factors is also an issue for future studies.
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Authors | U Ljøstad, A Mygland |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 17
Issue 1
Pg. 118-23
(Jan 2010)
ISSN: 1468-1331 [Electronic] England |
PMID | 19645771
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Ceftriaxone
- Doxycycline
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Ceftriaxone
(therapeutic use)
- Chronic Disease
(epidemiology)
- Comorbidity
- Doxycycline
(therapeutic use)
- Female
- Humans
- Leukocyte Count
(statistics & numerical data)
- Lyme Neuroborreliosis
(drug therapy, epidemiology, physiopathology)
- Male
- Middle Aged
- Prevalence
- Prospective Studies
- Risk Factors
- Sex Distribution
- Time
- Time Factors
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