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[Significance of opioid receptors in regulation of cardiac tolerance in pathogenic impact of long-term ischemia-reperfusion in vivo].

Abstract
The study aimed at investigation of the role of opioid receptor (OR) in regulation of cardiac tolerance to ischemia-reperfusion. Opioid receptor ligands and inhibitors were administered in vivo prior to coronary artery occlusion (45 min) and reperfusion (2 hrs). Occurring infraction size/area at risk (IS/AAR) ratio was determined. Pretreatment with the micro-OR agonists DAMGO and dermorphin H exerted no effect on the IS/AAR ratio. Activation of delta 1-OR by DPDPE did not alter cardiac tolerance in ischemia-reperfusion either. Pretreatment with the delta 2-OR agonists deltorphin D and deltorphin E or ORL1 receptor agonist nociceptin exerted no effect on the IS/AAR ratio. Stimulation of K-OR by selective agonists did not modify cardiac tolerance to ischemia-reperfusion. The delta 2-OR agonist deltorphin II significantly reduced the IS/AAR index. This effect was prevented by treatment with naltrexone, naloxone methiodide and the delta 2-OR antagonist naltriben but not by the delta 1-OR antagonist BNTX. The infarction-limiting effect of deltorphin II was also abolished by inhibition of protein kinase C (PKC) and mitochondrial Katp channels. Thus, the agonists of micro, delta 1, kappa, and ORL1 receptors in used doses did not affect cardiac tolerance in ischemia-reperfusion injury in vivo. The peripheral delta 2-OR activation induces infarction size reduction. Its infarction-reducing effect of deltorphin II is mediated via PKC activation and mitochondrial Katp, channel opening.
AuthorsL N Maslov, E I Barzakh, A V Krylatov, S A Brown, P R Oeltgen, M Govindaswami, G A Chernysheva, N V Solenkova, A Iu Lishmanov, S Iu Tsibul'nikov, T Krieg, E Zhang
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 95 Issue 6 Pg. 563-72 (Jun 2009) ISSN: 0869-8139 [Print] Russia (Federation)
PMID19639880 (Publication Type: English Abstract, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Analgesics, Opioid
  • Cardiotonic Agents
  • KATP Channels
  • Narcotic Antagonists
  • Receptors, Opioid
Topics
  • Analgesics, Opioid (pharmacology)
  • Animals
  • Cardiotonic Agents (pharmacology)
  • Disease Models, Animal
  • Hemodynamics (drug effects)
  • KATP Channels (metabolism)
  • Male
  • Myocardial Infarction (etiology, metabolism, physiopathology, prevention & control)
  • Myocardial Reperfusion Injury (complications, metabolism, physiopathology)
  • Myocardium (metabolism)
  • Narcotic Antagonists (pharmacology)
  • Rats
  • Rats, Wistar
  • Receptors, Opioid (agonists, metabolism)

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