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Bone marrow large B cell lymphoma bearing cyclin D3 expression: clinical, morphologic, immunophenotypic, and genotypic analyses of seven patients.

Abstract
We report seven large B cell lymphoma patients showing the involvement of tumor cells with cyclin D3 (CCND3) expression in bone marrow (BM) at the initial diagnosis. All patients presented with B symptoms, splenomegaly, and anemia/thrombocytopenia lacking hemophagocytosis in the BM. Five of the seven patients had suffered from immunological diseases or cancers. The tumor cells were divided into those with a lymphoplasmacytoid or blastoid appearance. Six cases were confirmed to express CD5 antigen on tumor cells. Three cases presented a chromosomal translocation between CCND3 and the immunoglobulin heavy chain (IGH) loci, t(6;14)(p21;q32). Three and two cases showed unmutated and mutated sequences of the variable region of IGH (VH), respectively, and one case showed deletion of an entire segment of VH. Two cases with t(6;14)(p21;q32) showed an unmutated VH sequence and chromosomal translocation within the switch region of IGH. Further studies are required to determine whether CCND3 expression is associated with a unique subset of diffuse large B cell lymphoma.
AuthorsJyuri Watanuki, Kinta Hatakeyama, Takashi Sonoki, Hiro Tatetsu, Katsuhiko Yoshida, Soichiro Fujii, Minoru Mizutani, Toru Abo, Miwa Kurimoto, Hiroshi Matsuoka, Fumihiko Matsuno, Hideki Nakakuma
JournalInternational journal of hematology (Int J Hematol) Vol. 90 Issue 2 Pg. 217-225 (Sep 2009) ISSN: 1865-3774 [Electronic] Japan
PMID19639271 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CCND3 protein, human
  • Cyclin D3
  • Cyclins
Topics
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes (pathology, physiology)
  • Bone Marrow Cells (pathology, physiology)
  • Cyclin D3
  • Cyclins (genetics)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genotype
  • Humans
  • Immunoglobulin Switch Region (genetics)
  • Immunophenotyping
  • Lymphoma, Large B-Cell, Diffuse (genetics, immunology, pathology)
  • Male
  • Middle Aged
  • Translocation, Genetic

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