[Successful treatment of Legionella pneumonia with moxifloxacin in a hemodialysis patient].

Abstract

Moxifloxacin, a recent, new quinolone agent, has superior pharmacokinetics and appears to be safe for patients with renal failure, as it is mainly excreted in the bile. The case of a hemodialysis patient with Legionella pneumonia who was successfully treated with moxifloxacin is reported. A 76-year-old woman, who had been on hemodialysis for chronic renal failure secondary to diabetic nephropathy, visited her hospital with a cough and fever. Pneumonia was diagnosed, and intravenous administration of cefotiam hydrochloride was begun, but her respiratory condition deteriorated. She was transferred to our hospital with dyspnea. A chest radiograph showed consolidation in both lung fields and cardiomegaly. A urinary antigen test for Legionella was positive. Legionella pneumonia with heart failure was diagnosed and she was started on 400 mg a day moxifloxacin. Her clinical condition improved. Moxifloxacin appears to be useful in the treatment of Legionella pneumonia in patients with renal failure.

• Authors: Osamu Takakuwa, Toshinobu Yamamoto, Atsuro Kawai, Masayoshi Torii, Atsushi Nakamura
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 47 Issue 7 Pg. 625-30 (Jul 2009) ISSN: 1343-3490 [Print] Japan
• PMID: 19637806 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Infective Agents
• Aza Compounds
• Fluoroquinolones
• Quinolines
• Moxifloxacin

Topics

• Aged
• Anti-Infective Agents (therapeutic use)
• Aza Compounds (therapeutic use)
• Female
• Fluoroquinolones
• Humans
• Legionnaires' Disease (drug therapy)
• Moxifloxacin
• Pneumonia, Bacterial (drug therapy)
• Quinolines (therapeutic use)
• Renal Dialysis