Abstract | BACKGROUND: METHODS: The study included 40 pediatric cardiosurgical patients with postoperative junctional ectopic tachycardia. Intravenous amiodarone in 2-mg/kg boluses and, if necessary, as continuous infusion (10 to 15 mug/kg/min), were used as the first-line therapy. Restoration of sinus rhythm or slowing of junctional ectopic tachycardia to a rate that allowed atrial or atrioventricular sequential pacing was considered as efficacy of therapy. RESULTS:
Amiodarone was effective in 18 patients (45%). Sinus rhythm was achieved in 7, and heart rate decreased in 11 patients from 180 (range, 173 to 200) to 142 (range, 133-155) beats/min (p < 0.0001) and allowed effective pacing with atrioventricular synchrony. Higher arteriovenous oxygen saturation difference (p = 0.007) and lower body temperature (p = 0.02) were associated with failure of amiodarone therapy. CONCLUSIONS:
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Authors | Lubica Kovacikova, Nina Hakacova, Dusan Dobos, Peter Skrak, Martin Zahorec |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 88
Issue 2
Pg. 616-22
(Aug 2009)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 19632422
(Publication Type: Journal Article)
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Chemical References |
- Anti-Arrhythmia Agents
- Amiodarone
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Topics |
- Amiodarone
(administration & dosage, therapeutic use)
- Anti-Arrhythmia Agents
(administration & dosage, therapeutic use)
- Blood Pressure
(drug effects)
- Cardiac Surgical Procedures
- Child
- Child, Preschool
- Combined Modality Therapy
- Female
- Heart Defects, Congenital
(surgery)
- Heart Rate
(drug effects)
- Humans
- Hypothermia, Induced
- Infant
- Infant, Newborn
- Male
- Postoperative Complications
(drug therapy)
- Prospective Studies
- Tachycardia, Ectopic Junctional
(drug therapy)
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