Abstract |
A 58-year-old man presented with jaundice 6 months after aortic valve replacement. Although non-A, non-B hepatitis was initially suspected, the final diagnosis of phenprocoumon ( Marcoumar)-induced hepatitis progressing to cirrhosis was based on recurrence of jaundice after re-exposure to the drug, improvement after withdrawal and centrilobular necrosis with eosinophilic infiltration in the liver biopsy. Antibodies to hepatitis C virus were absent. The aortic valve was replaced by a bioprosthesis to eliminate the need for life-long anticoagulation.
|
Authors | R A de Man, J H Wilson, S W Schalm, F J ten Kate, E van Leer |
Journal | Journal of hepatology
(J Hepatol)
Vol. 11
Issue 3
Pg. 318-21
(Nov 1990)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 1963177
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antibodies, Viral
- Phenprocoumon
|
Topics |
- Antibodies, Viral
(analysis, immunology)
- Chemical and Drug Induced Liver Injury
(diagnosis, immunology, pathology)
- Diagnosis, Differential
- Hepacivirus
(immunology)
- Hepatitis C
(diagnosis, immunology, pathology)
- Humans
- Liver
(pathology)
- Male
- Middle Aged
- Phenprocoumon
(adverse effects, therapeutic use)
- Thromboembolism
(drug therapy)
|