Abstract | PURPOSE: METHODS: Patients with acute central serous chorioretinopathy were chosen and treated with PDT with verteporfin. Decreasing doses of verteporfin were applied to the first 7 patients at 70%, 60%, 50%, 40%, 30%, 20%, and 10% of the full dose (6 mg/m). Other patients were treated with the effective lowest dose (30% of full dose). Fluorescein angiography, indocyanine green angiography, and optical coherence tomography recordings were performed before PDT and at 1 week, 2 weeks, 1 month, 3 months, 6 months, 9 months, and 12 months after PDT. The pretreatment and posttreatment best-corrected visual acuity were compared. RESULTS: Fifteen eyes of 15 patients with the diagnosis of acute central serous chorioretinopathy were chosen and treated with PDT. The results at each dose suggested that 30% of the full dose of verteporfin was the lowest effective dose. The mean improvement in visual acuity was 4.1 +/- 0.25 lines at follow-up (mean 11.8 months). No complications were found during observation, except 1 patient at 70% dose who developed retinal angiomatous proliferation at the 1-month follow-up. CONCLUSION: On the basis of the results of this study and available information regarding the expected rate of spontaneous resolution, 30% verteporfin dose seems to be safe and effective in the treatment of acute central serous chorioretinopathy.
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Authors | Ming-Wei Zhao, Peng Zhou, Hong-Xiang Xiao, Yong-Shun Lv, Chun-An Li, Guo-Dong Liu, Xiao-Xin Li |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 29
Issue 8
Pg. 1155-61
(Sep 2009)
ISSN: 1539-2864 [Electronic] United States |
PMID | 19629018
(Publication Type: Journal Article)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- Verteporfin
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Topics |
- Acute Disease
- Adult
- Aged
- Central Serous Chorioretinopathy
(drug therapy, pathology, physiopathology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Male
- Middle Aged
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, adverse effects)
- Porphyrins
(administration & dosage, adverse effects)
- Retina
(drug effects, pathology)
- Treatment Outcome
- Verteporfin
- Visual Acuity
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