Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions.

Abstract

This review article presents the fourth part (part D) in the series of stories on antiviral drug discovery. The stories told in part D focus on: (i) the cyclotriazadisulfonamide compounds; (ii) the {5-[(4-bromophenylmethyl]-2-phenyl-5H-imidazo[4,5-c]pyridine} compounds; (iii) (1H,3H-thiazolo[3,4-a]benzimidazole) derivatives; (iv) T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) and (v) its structurally closely related analogue pyrazine 2-carboxamide (pyrazinamide); (vi) new strategies for the treatment of hemorrhagic fever virus infections, including, as the most imminent, (vii) dengue fever, (viii) the veterinary use of acyclic nucleoside phosphonates; (ix) the potential (off-label) use of cidofovir in the treatment of papillomatosis, particularly RRP (recurrent respiratory papillomatosis); and (x) finally, the prophylactic use of tenofovir to prevent HIV infections.

• Authors: Erik De Clercq
• Journal: Medicinal research reviews (Med Res Rev) Vol. 30 Issue 4 Pg. 667-707 (Jul 2010) ISSN: 1098-1128 [Electronic] United States
• PMID: 19626594 (Publication Type: Journal Article, Review)

Chemical References

• Antiviral Agents
• Veterinary Drugs

Topics

• Animals
• Antiviral Agents (chemistry, pharmacology, therapeutic use)
• Drug Discovery
• Humans
• Veterinary Drugs (therapeutic use)
• Virus Diseases (drug therapy)